Study:
Protein malnutrition is the main determinant of frailty and sarcopenia in elderly people. Specific EAA mixture may contribute to slow-down mitochondrial dysfunction and to ameliorate clinical status.
Design:
- 155 elderly malnourished patients
- randomised in 2 groups: EAAs and placebo supplementation
- followed for 2 months
Measurements:
- oxidative stress in plasma
- mitochondrial production of ATP and cellular respiration in peripheral blood mononuclear cells.
Results:
nutritional status and general health
immune cell efficiency
cognitive performance
Mitochondrial ATP enhancement is associated with:
- improvement in “Tinetti Scale” (fall risk scale)
- improvement 4 metre
** Mini Mental State Examination
