Study:
Metabolic shifts and structural changes in the gut microbiota upon amino acid supplementation.
In order to slow down the ageing process.
Design:
Middle-aged mice (16 months) supplemented for 90 days with EAAs
Measurements:
- gut microbiota was analysed by 16S rDNA sequencing
Results:
Microbiota rebalancing
- Ageing leads to a reduction of the ratio Firmicutes/Bacterioides in the microbiota
- EAAs supplementation counteracts this reduction by lowering the
bacteria related to “inflamm-aging” (Bacterioides) - This leads to a “rejuvenation” of the microbiota.
Immunity activation
- EAAs supplementation halves the increase of the concentration of LBP
related to ageing. - This indicates a reduction of antigens in the gut and in the host
*Lipopolysaccharide Binding Protein (biomarker for the host inflammatory state)
