References by Therapeutic Areas

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1) Preclinical

Ragni M. et al.
Cancers (Basel)
14: 5691
2022

1.1)

Amino acids in cancer and cachexia: an integrated view

Ruocco C. et al.
Curr Opin Clin Nutr Metab Care
24: 88-95
2021

1.2)

Essential amino acid formulations to prevent mitochondrial dysfunction and oxidative stress

Ruocco C. et al.
Diabetes
69: 2324-2339
2020

1.3)

Manipulation of dietary amino acids prevents and reverses obesity in mice through multiple mechanisms that modulate energy homeostasis

Tedesco L. et al.
J Popul Ther Clin Pharmacol
27: e12-e21
2020

1.4)

Experimental evidence on the efficacy of two new metabolic modulators on mitochondrial biogenesis and function in mouse cardiomyocytes

Tedesco L. et al.
Nutrients
12: 282
2020

1.5)

A special amino-acid formula tailored to boosting cell respiration prevents mitochondrial dysfunction and oxidative stress caused by doxorubicin in mouse cardiomyocytes

Brunetti D. et al.
Front Pharmacol
11: 1171
2020

1.6)

Targeting multiple mitochondrial processes by a metabolic modulator prevents sarcopenia and cognitive decline in SAMP8 mice

Bifari et al.
Pharmacol Res.
158: 104863
2020

1.7)

Complete neural stem cell (NSC) neuronal differentiation requires a branched chain amino acids-induced persistent metabolic shift towards energy metabolism

D’Antona et al.
Cell Metab.
12, 362–372
2010

1.8)

Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice

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Bifari et al.
Genes Nutr.
12: 27
2017

1.9)

Amino acid supplements and metabolic health: a potential interplay between intestinal microbiota and systems control

Bifari and Nisoli Br.
J. Pharmacol
174:1336-1377
2017

1.10)

Branched-chain amino acids differently modulate catabolic and anabolic states in mammals: a pharmacological point of view

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2) Geriatrics:
Metabolic therapy in skeletal fractures, after hip replacement and in malnutrition / sarcopenia

Buondonno I. et al.
Clin Nutr.
39: 2080-2091
2020

2.1)

From mitochondria to healthy aging: the role of branched-chain amino acids treatment: MATeR a randomized study

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Aquilani R. et al.
Aging Clin Exp Res.
31: 157-160
2019

2.2)

Supplemented amino acids may enhance the walking recovery of elderly subjects after hip fracture surgery

Solerte B. et al.
Am J Cardiol.
101: 69E-77E
2008

2.3)

Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia

Fujita S. & Volpi E.
J Nutr.
136: 277S-280S
2006

2.4)

Amino acids and muscle loss with aging

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Rondanelli M. et al.
Clinical Nutri.
2011

2.5)

Effect of essential amino acid supplementation on quality of life, Amino acid profile and strength in institutionalized elderly patients

Park Y. et al.
Am J Clin Nutr.
108(5):1026-1033
2018 Nov 1

2.6)

Protein supplementation improves muscle mass and physical performance in undernourished prefrail and frail elderly subjects: a randomized, double-blind, placebo-controlled trial

Lancha AH Jr et al.
Amino Acids
49(1):33-47
2017 Jan

2.7)

Dietary protein supplementation in the elderly for limiting muscle mass loss

3) Motor rehabilitation:
Metabolic support in rehabilitation, strengthening the effectiveness of physiotherapy, pain reduction in physiotherapy

Landi F. et al.
Nutrients
14: 2316
2022

3.1)

Effects of a new multicomponent nutritional supplement on muscle mass and physical performance in adult and old patients recovered from Covid-19: a pilot observational case–control study

Rondanelli M. et al.
J Biol Regul Homeost Agents
34: 721-731
2020

3.2)

Effects of essential amino acid supplementation on pain in the elderly with hip fractures: a pilot, double-blind, placebo-controlled, randomised clinical trial

Aquilani R. et al.
Aging Clin Exp Res.
31: 157-160
2017

3.3)

Despite inflammation, supplemented essential amino acids may improve circulating levels of albumin and haemoglobin in patients after hip fractures

Rondanelli M. et al.
Aging Clin Exp Res.
29: 801-805
2017

3.4)

Plasma kinetics of essential amino acids following their ingestion as free formula or as dietary protein components

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Baldissaro E. et al.
Biomed Res Int.
2016: 9318329
2016

3.5)

The hip functional retrieval after elective surgery may be enhanced by supplemented essential amino acids

Aquilani R. et al.
Biomed Res Int.
2014: 341603
2014

3.6)

Essential amino acids and exercise tolerance in elderly muscle-depleted subjects with chronic diseases: a rehabilitation without rehabilitation?

4) Neurological rehabilitation:
Motor and cognitive recovery after stroke, reduction of dysphagia after stroke, cognitive recovery after head trauma, cognitive recovery in patients with post-traumatic coma

Boselli M. et al.
NeuroRehabilitation
42: 449-456
2018

4.1)

Inflammation and rehabilitation outcomes in patients with nontraumatic intracranial haemorrage

Aquilani R. et al.
Biomed Res Int
2014: 964365
2014

4.2)

Unaffected arm muscle hypercatabolism in dysphagic subacute stroke patients: the effects of essential amino acid supplementation

Aquilani R. et al.
Brain Inj
28: 161-73
2014

4.3)

Is stroke rehabilitation a metabolic problem?

Aquilani R. et al.
Nutr Clin Pract
26: 339-345
2011

4.4)

Nutrition for brain recovery after ischemic stroke: an added value to rehabilitation

Aquilani R. et al.
Nutr Neurosci
13: 129-134
2010

4.5)

Spontaneous neurocognitive retrieval of patients with sub-acute ischemic stroke is associated with dietary protein intake

Aquilani R. et al.
Arch Phys Med Rehabil
89: 1642-1647
2008

4.6)

Branched-chain amino acids may improve recovery from minimally conscious state in patients with traumatic brain injury: a pilot study

Aquilani R. et al.
Clin Rehabil
22: 1042-1050
2008

4.7)

Protein supplementation may enhance the spontaneous recovery of neurological alterations in patients with ischaemic stroke

Aquilani R. et al.
Nutr Neurosci
11: 235-240
2008

4.8)

Effect of calorie-protein supplementation on the cognitive recovery of patients with subacute stroke

Aquilani R. et al.
Arch Phys Med Rehabil
86: 1729-1735
2005

4.9)

Branched-chain amino acids enhance the cognitive recovery of patients with severe traumatic brain injury

Aquilani R. et al.
Eur Medicophys
35: 75-81
1999

4.10)

Prevalence of malnutrition and inadequate food intake in self-feeding rehabilitation patients with stroke

5) Cardiology:
Improvement of physical activity in chronic heart failure, reduction of insulin resistance, increase of aerobic activity, reduction of malnutrition/sarcopenia

Aquilani R. et al.
Nutrients
13: 1632
2021

5.1)

Altered amino acid metabolism in patients with cardiorenal syndrome type 2: is it a problem for protein and exercise prescriptions?

Lombardi C. et al.
Clin Med Insights Cardiol
8: 39-44
2014

5.2)

Effects of oral aminoacid supplements on functional capacity in patients with chronic heart failure

Macchi A. et al.
Med J Nutr Med
3: 209-214
2010

5.3)

The role of nutritional supplementation with essential amino acids in patients with chronic heart failure

Aquilani R. et al.
Am J Cardiol
101: 104e-110e
2008a

5.4)

Oral amino acid supplements improve exercise capacities in elderly patients with chronic heart failure

Aquilani R. et al.
Eur J Heart Fail
10: 1127-1135
2008b

5.5)

Adequate energy-protein intake is not enough to improve nutritional and metabolic status in muscle-depleted patients with chronic heart failure

Solerte B. et al.
Am J Cardiol
101(Suppl): 82E-88E
2008

5.6)

Improvement of blood glucose control and insulin sensitivity during a long-term (60 weeks) randomized study with amino acid dietary supplements in elderly subjects with type 2 diabetes mellitus

Scognamiglio R. et al.
Am J Cardiol
101: 111E-115E
2008

5.7)

Effects of oral amino acid supplements on cardiac function and remodeling in patients with type 2 diabetes with mild-to-moderate left ventricular dysfunction

Aquilani R. et al.
Am J Cardiol
93: 21A-22A
2004

5.8)

Oral amino acid administration in patients with diabetes mellitus: supplementation or metabolic therapy?

Pasini E. et al.
Ital Heart J
4: 232-235
2003

5.9)

Malnutrition, muscle wasting and cachexia in chronic heart failure: the nutritional approach

6) Nephrology:
Reduction of malnutrition/sarcopenia, reduction of anemia, increase of albuminemia in patients in hemodialysis

Murtas S. et al.
Nutrients
14: 3492
2022

6.1)

Effects of a novel amino acid formula on nutritional and metabolic status, anemia and myocardial function in thrice-weekly hemodialysis patients: results of a six-month randomized double-blind placebo-controlled pilot study

Aquilani R. et al.
Metabolites
12: 987
2022

6.2)

Effects of a metabolic mixture on gut inflammation and permeability in elderly patients with chronic kidney disease: a proof-of-concept study

Aquilani R. et al.
Nutrients
116: 1632
2021

6.3)

Altered amino acid metabolism in patients with cardiorenal syndrome type 2: is it a problem for protein and exercise prescriptions?

Murtas S. et al.
J Ren Nutr
30: 440-451
2020

6.4)

Differences and effects of metabolic fate of individual amino acid loss in high-efficiency hemodialysis and hemodiafiltration

Murtas S. et al.
J Ren Nutr
29: 126-135
2019

6.5)

Differences in amino acid loss between high-efficiency hemodialysis and postdilution and predilution hemodiafiltration using high convection volume exchange – A new metabolic scenario? A pilot study

Bolasco P. et al.
J Ren Nutr
62:211-212
2019

6.6)

Re. “Amino acid profile after oral nutritional supplementation in hemodialysis patients with protein-energy wasting”

Bolasco P. et al.
Ren Fail
33: 1-5
2011

6.7)

A novel amino acids oral supplementation in hemodialysis patients: a pilot study

Aquilani R. et al.
Nutrients
113, 1632
2021

6.8)

Altered Amino Acid Metabolism in Patients with Cardiorenal Syndrome Type 2: Is It a Problem for Protein and Exercise Prescriptions?

7) Pneumology or Pulmonology:
Reduction of sarcopenia and cachexia, increase of motor autonomy, reduction of cognitive dysfunction, improvement of the perception of well-being in patients with COPD

Dal Negro RW. et al.
Monaldi Arch Chest Dis
77: 67-75
2012

7.1)

Essential amino acid supplementation in patients with severe COPD: a step towards home rehabilitation

Dal Negro RW. et al.
Monaldi Arch Chest Dis
73: 25-33
2010

7.2)

Comprehensive effects of supplemented essential amino acids in patients with severe COPD and sarcopenia

Baldi S. et al.
Int J COPD
5: 29-39
2010

7.3)

Fat-free mass change after nutritional rehabilitation in weight losing COPD: role of insulin, C-reactive protein and tissue hypoxia

8) Infections and immune response:
Reduction of nosocomial infections in geriatrics and severe head trauma, strengthening of immunity acquired in strokes and geriatric patients

Nisoli E. et al.
Eat Weight Disord
26: 1647-1651
2021

8.1)

COVID-19 and Hartnup disease: an affair of intestinal amino acid malabsorption

Yang Z. et al.
Amino Acids
48: 2731-2745
2016

8.2)

Metabolic shifts and structural changes in the gut microbiota upon branched-chain amino acid supplementation in middle-aged mice

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Boselli M. et al.
Nutr Clin Pract.
27: 99-113
2012

8.3)

Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury

Aquilani R. et al.
Arch Gerontol Geriatr
52: e123-128
2011

8.4)

Effects of oral amino acid supplementation on long-term-care-acquired infections in elderly patients

Aquilani R. et al.
Arch Gerontol Geriatr
52: e123-128
2011

8.5)

EAAs included in the nutritional plan of patients in rehabilitation after ischemic stroke, are able to improve neuro-function abilities including deglutition and peripheral blood adaptive immunity.

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Del Giudice M. et al.
Brain, behavior and immunity
70 (2018) 61-75
2018

8.6)

Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters

Aquilani R. Arch.
Geriatric Gerontol.
52(3):e123-8
2011 May

8.7)

EAAs, included in the nutritional plan of patients in rehabilitation, are able to reduce the General Infection Rate

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9) Oncology:
Increased albumin, decreased ROS, increased weight in patients with cachexia

Aquilani R. et al.
Curr Oncol.
28: 3280-3296
2021

9.1)

Peripheral blood lymphocyte percentage may predict chemotolerance and survival in patients with advanced pancreatic cancer. association between adaptive immunity and nutritional state

Aquilani R. et al.
Nutrients
11: 2667
2019

9.2)

Oxaliplatin-fluoropyrimidine combination (XELOX) therapy does not affect plasma amino acid levels and plasma markers of oxidative stress in colorectal cancer surgery patients: a pilot study

Madeddu C et al.
Med J Nutr Med
3: 165-172
2010

9.3)

Open phase II study on efficacy and safety on an oral aminoacid functional cluster supplementation in cancer cachexia

10) Alzheimer:

Aquilani R. et al.
Nutrients
14: 1872
2022

10.1)

Is the Brain Undernourished in Alzheimer’s Disease?

Aquilani R. et al.
Nutrients
12: 1845
2020

10.2)

Mini nutritional assessment may identify a dual pattern of perturbed plasma amino acids in patients with Alzheimer’s disease: a window to metabolic and physical rehabilitation?