References by Therapeutic Areas

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Therapeutic Area



Clinical Evidence

1) Preclinical

Amino acids in cancer and cachexia: an integrated view

Essential amino acid formulations to prevent mitochondrial dysfunction and oxidative stress

Manipulation of dietary amino acids prevents and reverses obesity in mice through multiple mechanisms that modulate energy homeostasis

Experimental evidence on the efficacy of two new metabolic modulators on mitochondrial biogenesis and function in mouse cardiomyocytes

A special amino-acid formula tailored to boosting cell respiration prevents mitochondrial dysfunction and oxidative stress caused by doxorubicin in mouse cardiomyocytes

Targeting multiple mitochondrial processes by a metabolic modulator prevents sarcopenia and cognitive decline in SAMP8 mice

Complete neural stem cell (NSC) neuronal differentiation requires a branched chain amino acids-induced persistent metabolic shift towards energy metabolism

Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice

Amino acid supplements and metabolic health: a potential interplay between intestinal microbiota and systems control

Branched-chain amino acids differently modulate catabolic and anabolic states in mammals: a pharmacological point of view

2) Geriatrics:
Metabolic therapy in skeletal fractures, after hip replacement and in malnutrition / sarcopenia

From mitochondria to healthy aging: the role of branched-chain amino acids treatment: MATeR a randomized study

Supplemented amino acids may enhance the walking recovery of elderly subjects after hip fracture surgery

Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia

Amino acids and muscle loss with aging

Effect of essential amino acid supplementation on quality of life, Amino acid profile and strength in institutionalized elderly patients

Protein supplementation improves muscle mass and physical performance in undernourished prefrail and frail elderly subjects: a randomized, double-blind, placebo-controlled trial

Dietary protein supplementation in the elderly for limiting muscle mass loss

3) Motor rehabilitation:
Metabolic support in rehabilitation, strengthening the effectiveness of physiotherapy, pain reduction in physiotherapy

Effects of a new multicomponent nutritional supplement on muscle mass and physical performance in adult and old patients recovered from Covid-19: a pilot observational case–control study

Effects of essential amino acid supplementation on pain in the elderly with hip fractures: a pilot, double-blind, placebo-controlled, randomised clinical trial

Despite inflammation, supplemented essential amino acids may improve circulating levels of albumin and haemoglobin in patients after hip fractures

Plasma kinetics of essential amino acids following their ingestion as free formula or as dietary protein components

The hip functional retrieval after elective surgery may be enhanced by supplemented essential amino acids

Essential amino acids and exercise tolerance in elderly muscle-depleted subjects with chronic diseases: a rehabilitation without rehabilitation?

Comparison of protein- or amino acid-based supplements in the rehabilitation of men with severe obesity: a randomized controlled pilot study.

4) Neurological rehabilitation:
Motor and cognitive recovery after stroke, reduction of dysphagia after stroke, cognitive recovery after head trauma, cognitive recovery in patients with post-traumatic coma

Inflammation and rehabilitation outcomes in patients with nontraumatic intracranial haemorrage

Unaffected arm muscle hypercatabolism in dysphagic subacute stroke patients: the effects of essential amino acid supplementation

Is stroke rehabilitation a metabolic problem?

Nutrition for brain recovery after ischemic stroke: an added value to rehabilitation

Spontaneous neurocognitive retrieval of patients with sub-acute ischemic stroke is associated with dietary protein intake

Branched-chain amino acids may improve recovery from minimally conscious state in patients with traumatic brain injury: a pilot study

Protein supplementation may enhance the spontaneous recovery of neurological alterations in patients with ischaemic stroke

Effect of calorie-protein supplementation on the cognitive recovery of patients with subacute stroke

Branched-chain amino acids enhance the cognitive recovery of patients with severe traumatic brain injury

Prevalence of malnutrition and inadequate food intake in self-feeding rehabilitation patients with stroke

5) Cardiology:
Improvement of physical activity in chronic heart failure, reduction of insulin resistance, increase of aerobic activity, reduction of malnutrition/sarcopenia

Altered amino acid metabolism in patients with cardiorenal syndrome type 2: is it a problem for protein and exercise prescriptions?

Effects of oral aminoacid supplements on functional capacity in patients with chronic heart failure

The role of nutritional supplementation with essential amino acids in patients with chronic heart failure

Oral amino acid supplements improve exercise capacities in elderly patients with chronic heart failure

Adequate energy-protein intake is not enough to improve nutritional and metabolic status in muscle-depleted patients with chronic heart failure

Improvement of blood glucose control and insulin sensitivity during a long-term (60 weeks) randomized study with amino acid dietary supplements in elderly subjects with type 2 diabetes mellitus

Effects of oral amino acid supplements on cardiac function and remodeling in patients with type 2 diabetes with mild-to-moderate left ventricular dysfunction

Oral amino acid administration in patients with diabetes mellitus: supplementation or metabolic therapy?

Malnutrition, muscle wasting and cachexia in chronic heart failure: the nutritional approach

6) Nephrology:
Reduction of malnutrition/sarcopenia, reduction of anemia, increase of albuminemia in patients in hemodialysis

Effects of a novel amino acid formula on nutritional and metabolic status, anemia and myocardial function in thrice-weekly hemodialysis patients: results of a six-month randomized double-blind placebo-controlled pilot study

Effects of a metabolic mixture on gut inflammation and permeability in elderly patients with chronic kidney disease: a proof-of-concept study

Altered amino acid metabolism in patients with cardiorenal syndrome type 2: is it a problem for protein and exercise prescriptions?

Differences and effects of metabolic fate of individual amino acid loss in high-efficiency hemodialysis and hemodiafiltration

Differences in amino acid loss between high-efficiency hemodialysis and postdilution and predilution hemodiafiltration using high convection volume exchange – A new metabolic scenario? A pilot study

Re. “Amino acid profile after oral nutritional supplementation in hemodialysis patients with protein-energy wasting”

A novel amino acids oral supplementation in hemodialysis patients: a pilot study

Altered Amino Acid Metabolism in Patients with Cardiorenal Syndrome Type 2: Is It a Problem for Protein and Exercise Prescriptions?

7) Pneumology or Pulmonology:
Reduction of sarcopenia and cachexia, increase of motor autonomy, reduction of cognitive dysfunction, improvement of the perception of well-being in patients with COPD

Essential amino acid supplementation in patients with severe COPD: a step towards home rehabilitation

Comprehensive effects of supplemented essential amino acids in patients with severe COPD and sarcopenia

Fat-free mass change after nutritional rehabilitation in weight losing COPD: role of insulin, C-reactive protein and tissue hypoxia

8) Infections and immune response:
Reduction of nosocomial infections in geriatrics and severe head trauma, strengthening of immunity acquired in strokes and geriatric patients

COVID-19 and Hartnup disease: an affair of intestinal amino acid malabsorption

Metabolic shifts and structural changes in the gut microbiota upon branched-chain amino acid supplementation in middle-aged mice

Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury

Effects of oral amino acid supplementation on long-term-care-acquired infections in elderly patients

EAAs included in the nutritional plan of patients in rehabilitation after ischemic stroke, are able to improve neuro-function abilities including deglutition and peripheral blood adaptive immunity.

Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters

EAAs, included in the nutritional plan of patients in rehabilitation, are able to reduce the General Infection Rate

Essential Amino Acids as Immunonutrition in Critical Illness: Time for Trials?

9) Oncology:
Increased albumin, decreased ROS, increased weight in patients with cachexia

Peripheral blood lymphocyte percentage may predict chemotolerance and survival in patients with advanced pancreatic cancer. association between adaptive immunity and nutritional state

Oxaliplatin-fluoropyrimidine combination (XELOX) therapy does not affect plasma amino acid levels and plasma markers of oxidative stress in colorectal cancer surgery patients: a pilot study

Open phase II study on efficacy and safety on an oral aminoacid functional cluster supplementation in cancer cachexia

10) Alzheimer:

Is the Brain Undernourished in Alzheimer’s Disease?

Mini nutritional assessment may identify a dual pattern of perturbed plasma amino acids in patients with Alzheimer’s disease: a window to metabolic and physical rehabilitation?


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