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Clinical Evidence


EAAs supplementation supports the skeletal muscle mitochondrial biogenesis in middle-aged mice

Branched-chain amino acids differently modulate catabolic and anabolic states in mammals: a pharmacological point of view

Protein malnutrition is the main determinant of fraility and sarcopenia in elderly people. Specific EAA mixture may contribute to slow-down mitochondrial dysfunction and to ameliorate clinical status.

Aquilani R et al.
Intern J Inflamm Immunol
Cell Metabolism
Vol. 28(4) 576 –583

Del Giudice M. et al.
Brain, behavior and immunity
70 (2018) 61-75

EAAs included in the nutritional plan of patients in rehabilitation after ischemic stroke, are able to improve neuro-function abilities including deglutition and peripheral blood adaptive immunity.

EAAs, included in the nutritional plan of patients in rehabilitation, are able to reduce the General Infection Rate.

Age-associated loss of muscle mass and strength, with functional disabilities

Metabolic shifts and structural changes in the gut microbiota upon amino acid supplementation.

•In healthy elderly subjects the need for proteins is 1g/kg/day
•In elderly ill subjects the need is about 1,5g/kg/d (**)

Protein supplementation improves muscle mass and physical performance in undernourished prefrail and frail elderly subjects: a randomized, double-blind, placebo-controlled trial

Dietary protein supplementation in the elderly for limiting muscle mass loss

Scognamiglio R.
Am. J. Cardiol
2008 Suppl.

Effects of oral amino acid supplements on cardiac function and remodelling in patients with type 2 diabetes with mild-to-moderate left ventricular dysfunction.

Comprehensive effects of supplemented essential amino acids in patients with severe COPD and sarcopenia

Fat-free mass change after nutritional rehabilitation in weight losing COPD: role of insulin, C-reactive protein and tissue hypoxia

Improvement of Blood Glucose Control and Insulin Sensitivity During a Long-Term (60 Weeks) Randomized Study with Amino Acid Dietary Supplements in Elderly Subjects with Type 2 Diabetes Mellitus

Effect of essential amino acid supplementation on quality of life, Amino acid profile and strength in institutionalized elderly patients

Supplemented amino acids may enhance the walking recovery of elderly subjects after hip fracture surgery

Despite Inflammation, Supplemented Essential Amino Acids May Improve Circulating Levels of Albumin and Haemoglobin in Patients after Hip Fractures

The Hip Functional Retrieval after Elective Surgery May Be Enhanced by Supplemented Essential Amino Acids